کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1408820 | 1501699 | 2016 | 5 صفحه PDF | دانلود رایگان |
A comprehensive solid state study of Paroxetine nitrate hydrate, (PRX+·NO3−)H2O, is reported. This salt was characterized by a combination of methods, including Single crystal X-ray diffraction, Thermal analysis, Fourier transform infrared spectroscopy (FTIR) and Solubility measurements. (PRX+·NO3−)H2O crystallizes in the monoclinic C2 space group (Z′ = 1) and its packing was analyzed in details, showing that the main supramolecular motif consists in a C22(4) chain formed by charge-assisted N+-H⋯O− hydrogen bonds. The salt formation and conformation features were also accuracy established via FTIR spectra. In comparison with the pharmaceutical approved (PRX+⋅Cl−)⋅0.5H2O, (PRX+⋅NO3−)⋅H2O showed a decrease of 24 °C in the drug melting peak and a slight reduction in its water solubility value.
Figure optionsDownload as PowerPoint slide
Journal: Journal of Molecular Structure - Volume 1118, 15 August 2016, Pages 288–292