1H NMR study on the intermolecular interactions of macrocyclic and single α-amino acids

• The 1H NMR spectra of macrocyclic amino acid derivatives from L-tyrosine were analyzed.
• The formation of aggregates in solution is stabilized by π-stacking.
• Macrocyclic and simple amino acids are capable of retaining alcohol molecules.
• The alcohol molecule acts as a proton donor and the amino group acts as an acceptor.

Through analysis of 1H NMR spectra, evidence was found for intermolecular interactions between macrocyclic amino acid derivatives from L-tyrosine and their importance in the formation of aggregates in solution. It was also shown that both macrocyclic and simple amino acids are capable of retaining alcohol molecules through hydrogen bonding, where the alcohol molecule acts as a proton donor and the amino group acts as an acceptor.