کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1411204 1501851 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, characterization and DNA-binding studies of chiral ruthenium(II) complexes with 2-(5-nitrofuran-2-yl)-1H-imidazo[4,5-f][1,10]phenanthroline
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis, characterization and DNA-binding studies of chiral ruthenium(II) complexes with 2-(5-nitrofuran-2-yl)-1H-imidazo[4,5-f][1,10]phenanthroline
چکیده انگلیسی

Two new chiral ruthenium(II) complexes Δ-[Ru(bpy)2(nfip)]2+ and Λ-[Ru(bpy)2(nfip)]2+ (in which bpy = 2,2′-bipyridine, nfip = 2-(5-nitrofuran-2-yl)-1H-imidazo[4,5-f][1,10]phenanthroline) have been synthesized and characterized by elemental analysis, ES-MS, 1H NMR and CD spectra. The binding properties of two chiral complexes with calf thymus DNA have been investigated by different spectrophotometric methods and viscosity measurements. A subtle but detectable difference was observed in the interaction of both enantiomer with CT-DNA, Δ enantiomer binds with DNA more strongly than Λ enantiomer. Viscosity experiments provided evidence that both Δ-[Ru(bpy)2(nfip)]2+ and Λ-[Ru(bpy)2(nfip)]2+ bound to DNA by intercalation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Structure - Volume 963, Issues 2–3, 29 January 2010, Pages 153–159
نویسندگان
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