کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1423844 1509051 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bacteria responsive antibacterial surfaces for indwelling device infections
ترجمه فارسی عنوان
سطوح ضد باکتری واکنش باکتری ها برای عفونت های دستگاه تنفسی
کلمات کلیدی
بیوفیلم ها، عفونت ها، دستگاه های بیومدیکال، مسئول پپتیدها، انتشار کنترل شده
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
چکیده انگلیسی

Indwelling device infections now represent life-threatening circumstances as a result of the biofilms' tolerance to antibiotic treatments. Current antibiotic impregnation approaches through sustained antibiotic release have some unsolved problems which include short life-span, narrowed antibacterial spectrum, ineffectiveness towards resistant mutants, and the potential to hasten the antibiotic resistance process. In this study, bacteria responsive anti-biofilm surfaces were developed using bioactive peptides with proved activity to antibiotic resistant bacteria and biofilms. Resulting surfaces were stable under physiological conditions and in the presence of high concentrations of salts (0.5 M NaCl) and biomacromolcules (1.0% DNA and 2.0% alginate), and thus showed good biocompatibility to various tissue cells. However, lytic peptide immobilized surfaces could sense bacteria adhesion and kill attached bacteria effectively and specifically, so biofilms were unable to develop on the lytic peptide immobilized surfaces. Bacteria responsive catheters remained biofilm free for up to a week. Therefore, the bacteria responsive antibacterial surfaces developed in this study represent new opportunities for indwelling device infections.

Biofilm associated indwelling device infections represent life-threatening circumstances. Current antibiotic impregnation approaches through sustained antibiotic release have some unsolved problems. In this study, bacteria responsive anti-biofilm surfaces were developed using peptides with proved activity to antibiotic resistant bacteria and biofilms. Bacteria responsible catheters maintained biofilm free during a week of continuous cultivation.Figure optionsDownload high-quality image (95 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 198, 28 January 2015, Pages 18–25
نویسندگان
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