کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1424011 1509066 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Quantitative assessment of nanoparticle surface hydrophobicity and its influence on pulmonary biocompatibility
ترجمه فارسی عنوان
ارزیابی کمی از هیدروفوبیت سطح نانوذرات و تأثیر آن بر زیست سازگاری ریوی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
چکیده انگلیسی

To date, the role of nanoparticle surface hydrophobicity has not been investigated quantitatively in relation to pulmonary biocompatibility. A panel of nanoparticles spanning three different biomaterial types, pegylated lipid nanocapsules, polyvinyl acetate (PVAc) and polystyrene nanoparticles, were characterized for size, surface charge, and stability in biofluids. Surface hydrophobicity of five nanoparticles (50–150 nm) was quantified using hydrophobic interaction chromatography (HIC) and classified using a purpose-developed hydrophobicity scale: the HIC index, range from 0.00 (hydrophilic) to 1.00 (hydrophobic). This enabled the relationship between the nanomaterial HIC index value and acute lung inflammation after pulmonary administration to mice to be investigated. The nanomaterials with low HIC index values (between 0.50 and 0.64) elicited little or no inflammation at low (22 cm2) or high (220 cm2) nanoparticle surface area doses per animal, whereas equivalent surface area doses of the two nanoparticles with high HIC index values (0.88–0.96) induced neutrophil infiltration, elevation of pro-inflammatory cytokines and adverse histopathology findings. In summary, a HIC index is reported that provides a versatile, discriminatory, and widely available measure of nanoparticle surface hydrophobicity. The avoidance of high (HIC index > ~ 0.8) surface hydrophobicity appears to be important for the design of safe nanomedicines for inhalation therapy.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 183, 10 June 2014, Pages 94–104
نویسندگان
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