کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1424296 | 986712 | 2012 | 8 صفحه PDF | دانلود رایگان |
Herein we report on the development of a novel method of constraining a cell-penetrating peptide, which can be used to trigger transport of liposomes into cells upon in this case radiation with UV-light. A cell-penetrating peptide, which was modified on both termini with an alkyl chain, was anchored to the liposomal surface in a constrained and deactivated form. Since one of the two alkyl chains was connected to the peptide via a UV-cleavable linker, disconnection of this alkyl chain upon irradiation led to the exposure of the cell-penetrating peptide, and mediated the transport of the entire liposome particle into cells.
A novel method of constraining a cell-penetrating peptide, which can be used for triggered transport of liposomes into cells upon radiation with UV-light.Figure optionsDownload high-quality image (197 K)Download as PowerPoint slide
Journal: Journal of Controlled Release - Volume 164, Issue 1, 28 November 2012, Pages 87–94