کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1424695 986734 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Virus-like particles and α-galactosylceramide form a self-adjuvanting composite particle that elicits anti-tumor responses
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Virus-like particles and α-galactosylceramide form a self-adjuvanting composite particle that elicits anti-tumor responses
چکیده انگلیسی

Virus-like particles (VLP) are effective vehicles for delivery of heterologous antigen to antigen-presenting cells. However VLP alone are insufficiently stimulatory to generate the signals required to facilitate effective priming of naïve T cells. We show that the VLP derived from rabbit hemorrhagic disease virus can bind the galactose-containing adjuvant α-galactosylceramide to form a composite particle for co-delivery of antigen and adjuvant to the same antigen-presenting cell. Vaccination with VLP and α-galactosylceramide activated splenic iNKT cells to produce IFN-γ and IL-4, led to the generation of antigen-specific T cells that protected prophylactically against subcutaneous tumor challenge, and was more effective at generating anti-tumor immune responses than either component individually. These data demonstrate a novel method for immunopotentiating VLP to increase their efficacy in the generation of anti-tumor responses via the innate ligand recognition properties of calicivirus-derived nanoparticles.

Figure optionsDownload high-quality image (161 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 159, Issue 3, 10 May 2012, Pages 338–345
نویسندگان
, , , , , , , ,