کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1425881 986784 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Self-assembling peptide nanofiber scaffolds for controlled release governed by gelator design and guest size
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Self-assembling peptide nanofiber scaffolds for controlled release governed by gelator design and guest size
چکیده انگلیسی

The aim of this study was to develop controlled drug delivery by network scaffolds based on self-assembling peptide RADAFI and RADAFII. These two peptides self-assembled into interconnected nanofibrilar network structures with distinct physical morphologies. The hydrogels were also utilized for entrapment and release of some model guests, promising their future application as a drug delivery vehicle. Fickian diffusion controlled the release kinetics. Furthermore, the obtained release function was dependent on both rational design of the peptides used for hydrogel formation and choice of the entrapped molecules. On the basis of the striking different releases of these two peptide scaffolds, we suggested that guest size and lipophilicity influenced the release competitively. The release of RADAFI system was dominated by guest size, and the guest lipophilicity controlled the release behavior in RADAFII system. In a word, this work would potentially provide a spatially and temporally controlled delivery system for some functional drugs in the future.

Graphical AbstractThe release kinetics is dependent on both rational design of the peptides used for hydrogel formation and choice of the entrapped molecules.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 147, Issue 3, 1 November 2010, Pages 392–399
نویسندگان
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