کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1426107 986794 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Smart polyelectrolyte microcapsules as carriers for water-soluble small molecular drug
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Smart polyelectrolyte microcapsules as carriers for water-soluble small molecular drug
چکیده انگلیسی

Heat treatment is introduced as a simple method for the encapsulation of low molecular weight water-soluble drugs within layer-by-layer assembled microcapsules. A water-soluble drug, procainamide hydrochloride, could thus be encapsulated in large amount and enriched by more than 2 orders of magnitude in the assembled PDADMAC/PSS capsules. The shrunk capsules could control the unloading rate of drugs, and the drugs could be easily unloaded using ultrasonic treatment. The encapsulated amount could be quantitatively controlled via the drug concentration in the bulk. We also found that smaller capsules possess higher encapsulation capability.

A simple method for encapsulating water-soluble small molecular drugs within layer-by-layer assembled PDADMAC/PSS microcapsules is introduced. The encapsulated amount could be quantitatively controlled via the drug concentration in the bulk.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 139, Issue 2, 15 October 2009, Pages 160–166
نویسندگان
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