کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1426417 986811 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Benchtop-magnetic resonance imaging (BT-MRI) characterization of push–pull osmotic controlled release systems
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Benchtop-magnetic resonance imaging (BT-MRI) characterization of push–pull osmotic controlled release systems
چکیده انگلیسی

The mechanism of drug release from push–pull osmotic systems (PPOS) has been investigated by Magnetic Resonance Imaging (MRI) using a new benchtop apparatus. The signal intensity profiles of both PPOS layers were monitored non-invasively over time to characterize the hydration and swelling kinetics. The drug release performance was well-correlated to the hydration kinetics. The results show that (i) hydration and swelling critically depend on the tablet core composition, (ii) high osmotic pressure developed by the push layer may lead to bypassing the drug layer and incomplete drug release and (iii) the hydration of both the drug and the push layers needs to be properly balanced to efficiently deliver the drug. MRI is therefore a powerful tool to get insights on the drug delivery mechanism of push–pull osmotic systems, which enable a more efficient optimization of such formulations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 133, Issue 1, 5 January 2009, Pages 31–36
نویسندگان
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