کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1426909 986836 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Module assemblage technology for floating systems: In vitro flotation and in vivo gastro-retention
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Module assemblage technology for floating systems: In vitro flotation and in vivo gastro-retention
چکیده انگلیسی

The aim of this research was to study, in vitro by resultant-weight measurement and in vivo by γ-scintigraphy experiments in humans, the floatation behavior of systems obtained by modules assembled in void configuration. The assembled system technology allowed the manufacturing of a system characterized by the presence of an internal void space that provided an apparent density lower than water. The gastro-retention times of floating assembled systems were determined in comparison with non-floating systems having the same mass and composition. In vitro the floatation of the system started immediately after immersion in water and lasted for more than 5 h.The in vivo studies confirmed that the in vitro floating ability of void configuration was maintained also in the human stomach where the system stayed for periods of time ranging from 2.5 to 5.0 h, depending on the food regimen and the sex of the subject. Reiterate eating and drinking further prolonged the stomach residence time.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 129, Issue 2, 14 July 2008, Pages 88–92
نویسندگان
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