کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1426972 986840 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effective tumor regression by anti-neovascular therapy in hypovascular orthotopic pancreatic tumor model
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Effective tumor regression by anti-neovascular therapy in hypovascular orthotopic pancreatic tumor model
چکیده انگلیسی

Pancreatic cancer is one of the most serious cancers with poor therapeutic results and prognosis. In here, we proposed a novel treatment strategy of pancreatic cancer by injuring limited angiogenic vessels with liposome containing adriamycin. At first, we established an orthotopic tumor model, which has a hypovascular characteristic of pancreatic tumor. In this model, we obtained the enhanced therapeutic efficacy with liposome that modified by polyethylene glycol (PEG) and a peptide, Ala-Pro-Arg-Pro-Gly (APRPG), having an affinity to neovessels. Histochemical analysis suggested the degradation of angiogenic vessels after treatment with APRPG-PEG-liposomal adriamycin. In addition, we observed colocalization of fluorescence-labeled APRPG-PEG-liposome with angiogenic endothelial cells, although the biodistribution of 3H-labeled liposome did not show the difference in the amount of accumulation between PEG-modified liposome and APRPG-PEG-modified liposome. These results suggested the availability of the anti-neovascular therapy against pancreatic cancer and supply a new sight indication on chemotherapeutics against pancreatic cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 118, Issue 3, 23 April 2007, Pages 303–309
نویسندگان
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