کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1427067 | 986846 | 2007 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Enhancement of skin permeation of high molecular compounds by a combination of microneedle pretreatment and iontophoresis Enhancement of skin permeation of high molecular compounds by a combination of microneedle pretreatment and iontophoresis](/preview/png/1427067.png)
A combination of microneedle pretreatment and iontophoresis was evaluated for the potential to increase skin permeation of drugs. Two model compounds with low and high molecular D2O and fluorescein isothiocyanate (FITC)-dextrans (FD-4, FD-10, FD-40, FD-70 and FD-2000; average molecular weight of 3.8, 10.1, 39.0, 71.2 and 200.0 kDa), respectively, were used and the effect of microneedle pretreatment and iontophoresis on their in vitro permeability was evaluated using excised hairless rat skin with a 2-chamber diffusion cell. Convective solvent flow through the skin was measured using a set of calibrated capillaries attached to the diffusion cell. The following results were obtained: (1) convective solvent flow (electroosmosis) during iontophoresis through microneedle-pretreated skin, 2.62 ± 0.32 μL/cm2/h, was almost the same as through intact skin, 2.71 ± 0.25 μL/cm2/h, and (2) the combination of microneedle pretreatment and subsequent iontophoresis significantly enhanced FD flux compared with microneedle pretreatment alone or iontophoresis alone, whereas no synergistic effect was found on the flux of D2O. These results suggest that the combination of iontophoresis with microneedle pretreatment may be a useful means to increase skin permeation of high molecular compounds.
Journal: Journal of Controlled Release - Volume 118, Issue 2, 2 April 2007, Pages 189–195