کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1427194 986852 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats
چکیده انگلیسی

Nanoparticles prepared with a blend of a biodegradable polyester (poly(-ε-caprolactone)) and a polycationic non-biodegradable acrylic polymer (Eudragit® RS) have been used as a drug carrier for oral administration of insulin. The rate of encapsulation of insulin was around 96%. The therapeutic efficiency of oral insulin nanoparticles (25, 50 and 100 IU/kg) in diabetic rats and the intestinal uptake of fluorescein isothiocyanate (FITC) labelled insulin were studied. When administered orally by force-feeding to diabetic rats, insulin nanoparticles decreased fasted glycemia in a dose dependant manner with a maximal effect observed with 100 IU/kg. These insulin nanoparticles also increased serum insulin levels and improved the glycemic response to an oral glucose challenge for a prolonged period of time. FITC-Insulin-loaded nanoparticles strongly adhered to the intestinal mucosa and labeled insulin, either released and/or still inside nanoparticles, was mainly taken up by the Peyer's patches. It is concluded that polymeric nanoparticles allows the preservation of insulin's biological activity. In addition, the antidiabetic effect can be explained by the mucoadhesive properties of the polycationic polymer (Eudragit® RS) allowing the intestinal uptake of insulin.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 117, Issue 2, 12 February 2007, Pages 163–170
نویسندگان
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