کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1427420 | 986864 | 2006 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Inhibition of pulmonary metastasis in mice by all-trans retinoic acid incorporated in cationic liposomes Inhibition of pulmonary metastasis in mice by all-trans retinoic acid incorporated in cationic liposomes](/preview/png/1427420.png)
The purpose of this study was to investigate whether all-trans retinoic acid (ATRA), an active metabolite of retinal, incorporated in cationic liposomes composed of 1,2 dioleoyl-3-trimethylammonium propane (DOTAP)/cholesterol could inhibit established metastatic lung tumors by delivery to the pulmonary tumor site after intravenous injection. After intravenous injection in mice, the highest lung accumulation of [3H]ATRA was observed by the DOTAP/cholesterol liposomes formulation, while other formulations including [3H]ATRA dissolved in serum or [3H]ATRA incorporated in distearoyl-l-phosphatidylcholine (DSPC)/cholesterol liposomes produced little accumulation in the lung. In mice used as a model of lung cancer metastasis, ATRA incorporated in DOTAP/cholesterol liposomes, injected intravenously, reduced the number of tumor nodules compared with free ATRA or ATRA incorporated in DSPC/cholesterol liposomes. These results suggest that ATRA incorporated in cationic liposomes would be an effective strategy for differentiation therapy of lung cancer metastasis.
Journal: Journal of Controlled Release - Volume 116, Issue 1, 10 November 2006, Pages 58–63