کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1427671 986874 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel ultra-deformable vesicles entrapped with bleomycin and enhanced to penetrate rat skin
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Novel ultra-deformable vesicles entrapped with bleomycin and enhanced to penetrate rat skin
چکیده انگلیسی

Beta-sitosterol 3-β-d-glucoside (Sit-G), an absorption enhancer, was incorporated into ultra-deformable vesicles containing bleomycin to attenuate drug toxicity in human keratinocytes. The presence of Sit-G increased drug entrapment and improved in vitro stability of ultra-deformable vesicles. Confocal laser scanning microscopy revealed the extent to which Sit-G facilitated the penetration of ultra-deformable vesicles containing fluorescent probes into rat skin upon non-occlusive topical application. Furthermore, treatment with preparations incorporating Sit-G resulted in elevated epidermal and dermal concentrations of bleomycin. Ultra-deformable formulation contained Sit-G maintained flexibility for penetration through the skin, increased entrapment efficiency of bleomycin and stability in vitro, and significantly increased distribution of bleomycin in epidermis and dermis compared with those without Sit-G.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 113, Issue 2, 28 June 2006, Pages 146–154
نویسندگان
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