کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1429656 | 987177 | 2012 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Radiation synthesis of gelatin/CM-chitosan/β-tricalcium phosphate composite scaffold for bone tissue engineering Radiation synthesis of gelatin/CM-chitosan/β-tricalcium phosphate composite scaffold for bone tissue engineering](/preview/png/1429656.png)
A series of biodegradable composite scaffolds was fabricated from an aqueous solution of gelatin, carboxymethyl chitosan (CM-chitosan) and β-tricalcium phosphate (β-TCP) by radiation-induced crosslinking at ambient temperature. Ultrasonic treatment on the polymer solutions significantly influenced the distribution of β-TCP particles. An ultrasonic time of 20 min, followed by 30 kGy irradiation induced a crosslinked scaffold with homogeneous distribution of β-TCP particles, interconnected porous structure, sound swelling capacity and mechanical strength. Fourier Transform Infrared Spectroscopy and X-ray Diffraction analysis indicated that β-TCP successfully incorporated with the network of gelatin and CM-chitosan. In vivo implantation of the scaffold into the mandible of beagle dog revealed that the scaffolds had excellent biocompatibility and the presence of β-TCP can accelerate bone regeneration. The comprehensive results of this study paved way for the application of gelatin/CM-chitosan/β-TCP composite scaffolds as candidate of bone tissue engineering material.
► Radiation induced a crosslinked scaffold with interconnected porous structure.
► Ultrasonic time of 20 min led to homogenerously distribution of β-TCP.
► Increasing amount of β-TCP would restrict the swelling properties.
► Proper fraction of β-TCP will promote the mechanical properties of the scaffolds.
► Hybrid of β-TCP promoted the bone regeneration of the mandibles of beagle dogs.
Journal: Materials Science and Engineering: C - Volume 32, Issue 4, 1 May 2012, Pages 994–1000