کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1440041 1509273 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Applying terahertz technology for nondestructive detection of crack initiation in a film-coated layer on a swelling tablet
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Applying terahertz technology for nondestructive detection of crack initiation in a film-coated layer on a swelling tablet
چکیده انگلیسی

Here, we describe a nondestructive approach using terahertz wave to detect crack initiation in a film-coated layer on a drug tablet. During scale-up and scale-down of the film coating process, differences in film density and gaps between the film-coated layer and the uncoated tablet were generated due to differences in film coating process parameters, such as the tablet-filling rate in the coating machine, spray pressure, and gas–liquid ratio etc. Tablets using the PEO/PEG formulation were employed as uncoated tablets. We found that heat and humidity caused tablets to swell, thereby breaking the film-coated layer. Using our novel approach with terahertz wave nondestructively detect film surface density (FSD) and interface density differences (IDDs) between the film-coated layer and an uncoated tablet. We also found that a reduced FSD and IDD between the film-coated layer and uncoated tablet increased the risk of crack initiation in the film-coated layer, thereby enabling us to nondestructively predict initiation of cracks in the film-coated layer. Using this method, crack initiation can be nondestructively assessed in swelling tablets after the film coating process without conducting accelerated stability tests, and film coating process parameters during scale-up and scale-down studies can be appropriately established.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Results in Pharma Sciences - Volume 2, 2012, Pages 29–37
نویسندگان
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