کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
14983 1365 2015 19 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Circular code motifs near the ribosome decoding center
ترجمه فارسی عنوان
نقوش کد مدرن در نزدیکی مرکز رمزگشایی ریبوزوم
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی

A maximal C3 self-complementary trinucleotide circular code X is identified in genes of bacteria, eukaryotes, plasmids and viruses ( Michel, 2015 and Arquès and Michel, 1996). A translation (framing) code based on the circular code was proposed in Michel (2012) with the identification of several X circular code motifs (X motifs shortly) in both ribosomal RNAs (rRNAs) and their decoding center, and transfer RNAs (tRNAs). We extended these results in two ways. First, three universal X motifs were determined in the ribosome decoding center: the X motif mAA containing the conserved nucleotides A1492 and A1493, the X motif mG containing the conserved nucleotide G530 and the X motif m with unknown biological function ( El Soufi and Michel, 2014). Secondly, statistical analysis of X motifs of greatest lengths performed on different and large tRNA populations according to taxonomy, tRNA length and tRNA score showed that these X motifs have occurrence probabilities in the 5′ and/or 3′ regions of 16 isoaccepting tRNAs of prokaryotes and eukaryotes greater than the random case ( Michel, 2013). We continue here the previous works with the identification of X motifs in rRNAs of prokaryotes and eukaryotes near the ribosome decoding center. Seven X motifs PrRNAXm conserved in 16S rRNAs of prokaryotes P and four X motifs ErRNAXm conserved in 18S rRNAs of eukaryotes E are identified near the ribosome decoding center. Furthermore, four very large X motifs of length greater than or equal to 20 nucleotides, 14 large X motifs of length between 16 and 19 nucleotides and several X motifs of length greater or equal to 9 nucleotides are found in tRNAs of prokaryotes. Some properties of these X motifs in tRNAs are described. These new results strengthen the concept of a translation code based on the circular code ( Michel, 2012).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computational Biology and Chemistry - Volume 59, Part A, December 2015, Pages 158–176
نویسندگان
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