کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
149998 456441 2012 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, micellization and caffeine drug release kinetics of novel PBMA-b-PNIPAAm block polymer brushes
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Synthesis, micellization and caffeine drug release kinetics of novel PBMA-b-PNIPAAm block polymer brushes
چکیده انگلیسی

Brush-like block copolymers with poly(t-butyl methacrylate) (PBMA) and poly(N-ispropylacrylamide) (PNIPAAm) as side arms, PBMA-b-PNIPAAm, were designed and synthesized via a simple free radical polymerization route. The chemical structure and molecular weight of these polymer brushes were characterized and determined by nuclear magnetic resonance (1H NMR), Fourier transform infrared spectrometry (FT-IR) and gel permeation chromatography (GPC). The polymer brushes can spontaneously assembled into regularly spherical core–shell nanostructured micelles with well-dispersed individual nanoparticles in aqueous solutions, and physiochemical properties of the micelles formed were detected by a surface tension technique, nanoparticle analyzer, transmission electron microscope (TEM), dynamic light scattering (DLS) and UV–vis transmittance measurements. Low critical micelle concentration (CMC) and high zeta potentials revealed the micellar stability and the micellar particle size was in the range from 36 to 93 nm by TEM and less than 200 nm by DLS. The resulting block polymer brushes were temperature-sensitive with low critical solution temperature (LCST) about 28.80–29.40 °C. These characteristic parameters were affected by their compositional ratios and the length of hydrophilic or hydrophobic chains. The evaluation for caffeine drug release and release kinetics demonstrated that the drug release and bioavailability may be mediated or improved by the temperature-induced structural changes of the micelles and different diffusion mechanism.

Figure optionsDownload as PowerPoint slideHighlights
► We have synthesized thermosensitive amphiphilic block copolymer brushes.
► The copolymer brushes could self-assemble and form nanoleveled spherical micelles.
► The self-assembled micelles exhibited thermal-triggered response properties.
► The micellar sizes depended on the mass ratios or the chain length of each component.
► The micelles were of thermodynamic stability and can be used in controlled drug release.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemical Engineering Journal - Volumes 189–190, 1 May 2012, Pages 431–442
نویسندگان
, , ,