کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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15150 | 1382 | 2013 | 6 صفحه PDF | دانلود رایگان |
We study the geometric modeling approach to estimating the null distribution for the empirical Bayes modeling of multiple hypothesis testing. The commonly used method is a nonparametric approach based on the Poisson regression, which however could be unduly affected by the dependence among test statistics and perform very poorly under strong dependence. In this paper, we explore a finite mixture model based geometric modeling approach to empirical null distribution estimation and multiple hypothesis testing. Through simulations and applications to two public microarray data, we will illustrate its competitive performance.
Figure optionsDownload as PowerPoint slideHighlights
► A flexible modeling approach to estimating empirical null distribution for appropriate control of false positives.
► Detailed simulation studies demonstrating the very competitive performance of the proposed method.
► Applications to two microarray data illustrating the favorable performance of the proposed method.
Journal: Computational Biology and Chemistry - Volume 43, April 2013, Pages 17–22