کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
15173 1385 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
miRNA and tropism of human parvovirus B19
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
miRNA and tropism of human parvovirus B19
چکیده انگلیسی

Parvovirus B19 has an extreme tropism for human erythroid progenitors. Here we propose the hypothesis explaining the tropism of human parvovirus B19. Our speculations are based on experimental results related to the capsid proteins VP1 and VP2. These proteins were not detectable in nonpermissive cells in course of these experiments, although the corresponding mRNAs were synthesized. Our interpretation of these results is an inhibition of translation in nonpermissive cells by human miRNAs. We bring support to our hypothesis and propose detailed experimental procedure to test it.


► We propose a different interpretation of the results of the published experiments.
► We propose the hypothesis explaining the tropism of human parvovirus B19.
► We explain the change in protein production in nonpermissive cells by codon optimization.
► Our explanation is inhibition of translation in nonpermissive cells by human miRNAs.
► We brought support to our hypothesis and proposed experimental procedures to test it.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computational Biology and Chemistry - Volume 40, October 2012, Pages 1–6
نویسندگان
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