کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
15357 1406 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A method for discovering transmembrane beta-barrel proteins in Gram-negative bacterial proteomes
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
A method for discovering transmembrane beta-barrel proteins in Gram-negative bacterial proteomes
چکیده انگلیسی

Transmembrane β-barrel (TMB) proteins play pivotal roles in many aspects of bacterial functions. This paper presents a k-nearest neighbor (K-NN) method for discriminating TMB and non-TMB proteins. We start with a method that makes predictions based on a distance computed from residue composition and gradually improve the prediction performance by including homologous sequences and searching for a set of residues and di-peptides for calculating the distance. The final method achieves an accuracy of 97.1%, with 0.876 MCC, 86.4% sensitivity and 98.8% specificity. A web server based on the proposed method is available at http://yanbioinformatics.cs.usu.edu:8080/TMBKNNsubmit.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computational Biology and Chemistry - Volume 32, Issue 4, August 2008, Pages 298–301
نویسندگان
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