کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
154060 | 456552 | 2008 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and stealthing study of bare and PEGylated silica micro- and nanoparticles as potential drug-delivery vectors
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and stealthing study of bare and PEGylated silica micro- and nanoparticles as potential drug-delivery vectors Synthesis and stealthing study of bare and PEGylated silica micro- and nanoparticles as potential drug-delivery vectors](/preview/png/154060.png)
چکیده انگلیسی
Bare and PEGylated silica spheres have been synthesized and characterized in order to study their potential application as intravenous drug-delivery vectors. Solubility under physiological conditions (in simulated body fluid) as well as standard protein adsorption experiments (immobilization of bovine serum albumin, BSA) were carried out in order to analyze the stability and the potential avoidance of the reticuloendothelial system (RES) achieved after PEGylation. The influences of the chain length of the PEG, as well as, of the temperature in the esterification reaction were also analyzed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemical Engineering Journal - Volume 137, Issue 1, 15 March 2008, Pages 45–53
Journal: Chemical Engineering Journal - Volume 137, Issue 1, 15 March 2008, Pages 45–53
نویسندگان
Clara Yagüe, María Moros, Valeria Grazú, Manuel Arruebo, Jesús Santamaría,