کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1641657 | 1517226 | 2016 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Strategies to incorporate polyelectrolyte in emulsion electrospun nanofibrous tissue engineering scaffolds for modulating growth factor release from the scaffolds
ترجمه فارسی عنوان
استراتژی برای ترکیب پلی الکترولیت در داربست های مهندسی بافت نانوی فیبر امولسیونی برای تخلیه آزادسازی عامل رشد از داربست
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
فناوری نانو (نانو تکنولوژی)
چکیده انگلیسی
Nanofibrous scaffolds made by electrospinning are shown to have distinctive advantages, including the biomimicking structure and ease of incorporating growth factors (GFs), in tissue engineering. However, the initial burst release of GFs is difficult to avoid in GF-incorporated scaffolds made by conventional emulsion electrospinning. As growth factors bear electrical charge, incorporating opposite charge species in scaffolds may modulate GF release. In this investigation, two strategies were demonstrated to incorporate a negatively charged polyelectrolyte, cellulose acetate (CA), into emulsion electrospun poly(lactic-co-glycolic acid) scaffolds containing a positively charged GF, basic fibroblast growth factor (bFGF). It was shown that with CA incorporation, the release of bFGF from scaffolds was modulated. An enhanced, steady and sustained release of bFGF was achieved for scaffolds made by coaxial emulsion electrospinning.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Letters - Volume 162, 1 January 2016, Pages 48-52
Journal: Materials Letters - Volume 162, 1 January 2016, Pages 48-52
نویسندگان
Qilong Zhao, Min Wang,