Biomimetic synthesis of hollow calcium phosphate nanospheres on core–shell structured electrospun calcium lactate/nylon-6 nanofibers

The aim of this study was to investigate into calcium phosphate (CaP) nucleation and growth on the electrospun nylon-6 nanofibers having its own and added functionalities of lactic acid (LA) and calcium lactate (CL) obtained by novel coating technique. LA was simply incorporated into the nylon-6 fibers by means of simple blending prior to electrospinning where as CL was deposited on the surface of as-formed core–shell structured fibers via simple acid–base neutralization. The bone formation ability of different functional groups on the fiber was evaluated by incubating in simulated body fluid. This study demonstrated a functionalities depended nucleation and growth mechanism of hollow CaP nanosphere on the surface of polymeric nanofibers.

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► Hollow CaP nanosphere were deposited on spider-wave-like nylon-6 nanonets.
► Functionalities depended mineralization of CaP was demonstrated.
► Core–shell structured nanofibrous mat was fabricated by single spinneret electrospinning.