کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1695841 | 1011878 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Tramadol hydrochloride/montmorillonite composite: Preparation and controlled drug release
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
علوم زمین و سیارات
ژئوشیمی و پترولوژی
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چکیده انگلیسی
The adsorption of tramadol hydrochloride (TH) by montmorillonite (MMT) was investigated, to obtain a controlled drug release system. The adsorption isotherm was fitted by the Langmuir model and followed the pseudo-second-order kinetics. The composite was characterized by XRD, FTIR and TG-DTA. TH was intercalated into MMT in vertical orientation giving a basal spacing of 1.99 nm. Release of the intercalated TH was studied in simulated gastric fluid (SGF, pH = 1.2) and simulated intestinal fluid (SIF, pH = 7.4) at 37 °C. Controlled release of TH from TH/MMT was observed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Clay Science - Volume 49, Issue 3, July 2010, Pages 108–112
Journal: Applied Clay Science - Volume 49, Issue 3, July 2010, Pages 108–112
نویسندگان
Youmei Chen, Anning Zhou, Bo Liu, Jun Liang,