Time-optimal operation of multi-component batch diafiltration

• Batch diafiltration process is studied in case of multi-component solution.
• Optimal control structure derived analytically under several operational constraints.
• Experimentally validated model is employed to illustrate the benefits.
• Case studies show an improved performance using the optimal operation by up to 38%.

We study the minimum-time operation of batch multi-component diafiltration processes. We employ the technique of Pontryagin's minimum principle to derive the candidates for an optimal operation. The optimal operation is defined as a state-feedback strategy. Simulations and numerical optimizations are applied to confirm the optimality of the proposed time-optimal operation. Obtained results are evaluated on two case studies, a typical multi-component diafiltration processes. Standard operational approaches are compared to the optimal operation and the resulting improvements show attractivity of the proposed approach.

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