Simultaneous regular and non-regular production scheduling of multipurpose batch plants: A real chemical–pharmaceutical case study

• We propose a solution approach that considers the integration of campaign and short-term scheduling in multipurpose batch plants.
• We develop a rolling horizon approach and a reformulation to deal with the computational complexity of the scheduling problem.
• The proposed methods were tested in a real world scheduling problem from the chemical–pharmaceutical industry.

Regular and non-regular production can often be found in multipurpose batch plants, requiring two distinct operating strategies: campaign and short-term production. This paper proposes a solution approach for simultaneous scheduling of campaign and short-term products in multipurpose batch plants. Regular products follow a cyclic schedule and must cover several product deliveries during the scheduling horizon, while non-regular products have a non-cyclic schedule. The proposed approach explores the Resource-Task Network (RTN) discrete-time formulation. Moreover, a rolling horizon approach, and reformulation and branching strategies have been applied to deal with the computational complexity of the scheduling problem. Real case instances of a chemical–pharmaceutical industry are solved, showing the applicability of the solution approach.