کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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173512 | 458597 | 2008 | 6 صفحه PDF | دانلود رایگان |

In this article we address the steady state design of a nonlinear tryptophan biosynthesis model with guaranteed stability of the optimal solution in the presence of parametric uncertainty. The optimization based approach – denoted constructive nonlinear dynamics (CNLD) – is based on constraints that enforce a minimal distance in the space of the uncertain parameters between a stability boundary and the optimal solution. The results obtained with CNLD are compared to results recently presented by Chang and Sahinidis [Chang, Y. J., & Sahinidis, N. V. (2005). Optimization of metabolic pathways under stability considerations. Computers and Chemical Engineering, 29 (3), 467–479], where the optimization of the tryptophan biosynthesis model was addressed by a global optimization algorithm. CNLD takes the nonlinearities of the process exactly into account and satisfies the specified robustness criteria without being overly conservative.
Journal: Computers & Chemical Engineering - Volume 32, Issue 12, 22 December 2008, Pages 2914–2919