کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
173594 458600 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Optimal intravenous bolus-infusion drug-dosage regimen based on two-compartment pharmacokinetic models
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Optimal intravenous bolus-infusion drug-dosage regimen based on two-compartment pharmacokinetic models
چکیده انگلیسی

An orthogonal collocation on finite elements-based regression method was applied to help design optimal drug-dosage regimens. The approach, suitable for two-compartment models, would allow clinicians to design multiple boluses followed by a constant-rate infusion of a medicament to patients in order to assure a desired plasma concentration. The algorithm was tested on theophylline, a drug that has been described by both linear and Michaelis–Menten elimination pharmacokinetics. In the linear case, increasing the number of boluses, from 1 to 4, decreased the normalized square root of the integral square error from 1.80 to 0.58 when a target concentration of 10 μg/mL was selected in the central compartment. When applied to the nonlinear metabolism, the procedure, implemented in Mathematica® (Wolfram Research, Inc.), effectively computed optimal dose sizes, injection times and infusion rates. Estimations, based on linear interpolation, provided a good time-saving alternative to the full optimization methodology.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computers & Chemical Engineering - Volume 33, Issue 6, 16 June 2009, Pages 1212–1219
نویسندگان
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