کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1762098 | 1019677 | 2010 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Prolonged Endochondral Bone Healing in Senescence is Shortened by Low-Intensity Pulsed Ultrasound in a Manner Dependent on COX-2
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
آکوستیک و فرا صوت
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Prolonged Endochondral Bone Healing in Senescence is Shortened by Low-Intensity Pulsed Ultrasound in a Manner Dependent on COX-2 Prolonged Endochondral Bone Healing in Senescence is Shortened by Low-Intensity Pulsed Ultrasound in a Manner Dependent on COX-2](/preview/png/1762098.png)
چکیده انگلیسی
To test whether mechanical loading produces faster healing in aged mice, fractured femurs of aged 1-year-old mice were subjected to low-intensity pulsed ultrasound (LIPUS), a treatment that is routinely used to help heal fractures in humans. Cyclooxygenase-2 knockout mice (COX-2â/â), which lack an immediate early mediator of mechanical stimulation, were also studied by histochemistry, microcomputed tomography and quantitative polymerase chain reaction to determine the role of COX-2. The healing in the aged COX-2â/â mice is slow during the endochondral bone remodeling (>30 d), a period generally prolonged in senescence. For aged wild-type mice, LIPUS halved the endochondral phase to about 10 d, whereas that was not the case for aged COX-2â/â mice, which showed no apparent shortening of the prolonged endochondral-phase healing time. Injecting prostaglandin E2 receptor agonists, however, rescued the COX-2â/â callus from insensitivity to LIPUS. In conclusion, COX-2 is a limiting factor in the delayed endochondral bone healing and is induced by LIPUS, which normalizes healing rate to the wild-type level. (E-mail: yukomtak@kdcnet.ac.jp)
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasound in Medicine & Biology - Volume 36, Issue 7, July 2010, Pages 1098-1108
Journal: Ultrasound in Medicine & Biology - Volume 36, Issue 7, July 2010, Pages 1098-1108
نویسندگان
Kouji Naruse, Hideki Sekiya, Yoshihumi Harada, Sadahiro Iwabuchi, Yusuke Kozai, Ryota Kawamata, Isamu Kashima, Kentaro Uchida, Ken Urabe, Kannichi Seto, Moritoshi Itoman, Yuko Mikuni-Takagaki,