کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1767132 | 1020177 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Early effects of carbon-ion irradiation on murine lymphocytes and thymocytes
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
علوم زمین و سیارات
علوم فضا و نجوم
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Early effects of carbon-ion irradiation on murine lymphocytes and thymocytes Early effects of carbon-ion irradiation on murine lymphocytes and thymocytes](/preview/png/1767132.png)
چکیده انگلیسی
To estimate the biological risks from space radiation encountered by cosmonauts in outer space, the effects from whole-body exposure to carbon ions or X-rays irradiations at 0, 0.39, 0.55 and 1Â Gy at a dose rate of 0.2Â Gy/min were investigated in BALB/c mice. The relative thymus and spleen weights were measured at 24Â h after exposure, and the cell cycle distribution and percentage of apoptosis of thymocytes and spleen and peripheral blood lymphocytes were determined by flow cytometry. The data showed that exposure to carbon ions delayed cell progression of peripheral blood lymphocytes in S-phase, and delayed thymocytes and spleen lymphocytes in G0/G1-phase. Apoptosis of thymocytes and peripheral blood lymphocytes induced by carbon ions increased more rapidly with dose than was the case for X-rays. There were some differences between the relative weight loss of the thymus and the spleen with increasing dose of either carbon ions or X-rays. The results obtained provide evidence of dose- and organ-specific differences induced by carbon ions compared to X-rays, with increased apoptosis in peripheral blood lymphocytes and thymocytes, but not spleen lymphocytes. Our data may suggest that further work would be of interest to estimate risk of changes in immune function during particle radiation exposures in space travel.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advances in Space Research - Volume 40, Issue 4, 2007, Pages 563-567
Journal: Advances in Space Research - Volume 40, Issue 4, 2007, Pages 563-567
نویسندگان
Yi Xie, Hong Zhang, Bingrong Dang, Tao Bing, Jifang Hao, Hongyun Guo, Xiaohu Wang,