کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1792515 1023648 2010 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lactose particle engineering: Influence of ultrasound and anti-solvent on crystal habit and particle size
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم فیزیک ماده چگال
پیش نمایش صفحه اول مقاله
Lactose particle engineering: Influence of ultrasound and anti-solvent on crystal habit and particle size
چکیده انگلیسی

This study focuses on ultrasound-assisted anti-solvent crystallization of lactose, expanding on previous studies and presenting, for the first time, the results of large scale implementation of sonocrystallization for lactose. The results further clarify the interplay between solution chemistry – namely the role of β-lactose – and crystallization, representing a step forward in the fine tuning of lactose properties for pharmaceutical manufacturing applications. Batches manufactured at laboratory and pilot scales were extensively characterised, including an approach for the quantification of β-lactose in α-lactose based on powder X-ray diffraction (PXRD), which is described here.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Crystal Growth - Volume 312, Issue 23, 15 November 2010, Pages 3509–3520
نویسندگان
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