کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1811906 | 1025604 | 2011 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of long-term physical aging on the kinetic parameters in a common pharmaceutical drug: Flutab®
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
فیزیک ماده چگال
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![عکس صفحه اول مقاله: Effect of long-term physical aging on the kinetic parameters in a common pharmaceutical drug: Flutab® Effect of long-term physical aging on the kinetic parameters in a common pharmaceutical drug: Flutab®](/preview/png/1811906.png)
چکیده انگلیسی
Differential scanning calorimetry (DSC) measurements were performed to investigate the effects of long-term physical aging on kinetic parameters of the pharmaceutical drug (Flutab®). Kinetics parameters such as activation energy (E) and fragility parameter (m) of the glass transition for aged and rejuvenated glasses were determined using different kinetic models. Evidence of variation of E with temperature is presented. It is shown in this work that natural storage of the drug introduced significant physical aging as indicated by changes in the glass transition temperature, activation energy and fragility parameter.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physica B: Condensed Matter - Volume 406, Issue 3, 1 February 2011, Pages 319-323
Journal: Physica B: Condensed Matter - Volume 406, Issue 3, 1 February 2011, Pages 319-323
نویسندگان
A.A. Abu-Sehly, A.A. Elabbar,