کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
183714 | 459556 | 2015 | 8 صفحه PDF | دانلود رایگان |
An interesting sequence of oxidation/Michael addition/oxidation/spirocyclization is observed in the electrolysis of caffeic acid esters in the presence of barbituric acid derivatives leading to the synthesis of a series of novel spirocycles. In an experimentally simple and clean procedure, the electrolyses proceed via a domino of electrochemical (E) and chemical (C) events with employing electrons as the only reagents in aqueous solution without introducing any catalyst or oxidant. From mechanistic point of view, a new type of domino mechanism (ECECi, Ci = spirocyclization) is proven with a unique Ci phenomenon at final step. Also, in light of experimental and theoretical NMR investigations, highly chemo and regioselectivities have been detected in these synthetic electrolyses.
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Journal: Electrochimica Acta - Volume 178, 1 October 2015, Pages 533–540