کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1851888 1033843 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Remote-controlled module-assisted synthesis of O-(2-[18F]fluoroethyl)-L-tyrosine as tumor PET tracer using two different radiochemical routes
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم فیزیک هسته ای و انرژی بالا
پیش نمایش صفحه اول مقاله
Remote-controlled module-assisted synthesis of O-(2-[18F]fluoroethyl)-L-tyrosine as tumor PET tracer using two different radiochemical routes
چکیده انگلیسی
The positron-emitter fluorine-18 labeled amino acid O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) has shown very promising perspectives for brain tumor diagnosis with positron emission tomography (PET). There have been two existing preparation routes of [18F]FET named direct nucleophilic radiofluorination of protected L-tyrosine and radiofluoroalkylation of unprotected L-tyrosine, respectively. A general module was designed specifically for the routine synthesis of [18F]FET, which could be suitable for the present two chemical methods with simple modifications. The fluorinated intermediates and the final product were separated and purified using solid phase extraction (SPE) on the Sep-Pak silica plus cartridge instead of the time-consuming high performance liquid chromatography (HPLC) procedures. The total synthesis time was about 50-60 min with good radiochemical yield (about 20-40%, no-decay-corrected) and good radiochemical purity (more than 97%) for both the synthetic methods.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nuclear Science and Techniques - Volume 17, Issue 3, June 2006, Pages 148-153
نویسندگان
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