Application of single-vial ready-for-use formulation of 111In- or 177Lu-labelled somatostatin analogs

• Optimal quencher combination: ascorbic- and gentisic acid and ethanol.
• Used quencher concentrations had no effect on pharmacokinetics.
• Purging the reaction mixture with N2 after radiolabelling resulted in 10% higher RCP.
• Quencher mixture stabilize 111In- and 177Lu-labelled SS-analogs during 7 days.
• Enables to store and transport 111In- and 177Lu-labelled SS-analogs in a single-vial.

For the sake of safety it would be desirable to store and transport the ready-for-use liquid formulation (diagnostics and therapeutics) of radiolabelled peptides. The use of ethanol, in combination with a mixture of gentisic- and ascorbic acid, has superior effects on stabilizing radiolabelled somatostatin analogs. As a consequence, 111In- and 177Lu-labelled somatostatin analogs can be stored and transported in a single-vial ready-for-use liquid formulation up to 7 days after radiolabelling.