کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1877759 1042239 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Boron neutron capture therapy induces cell cycle arrest and DNA fragmentation in murine melanoma cells
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم تشعشع
پیش نمایش صفحه اول مقاله
Boron neutron capture therapy induces cell cycle arrest and DNA fragmentation in murine melanoma cells
چکیده انگلیسی

The melanoma is a highly lethal skin tumor, with a high incidence. Boron Neutron Capture Therapy (BNCT) is a radiotherapy which combines Boron with thermal neutrons, constituting a binary system.B16F10 melanoma and L929 fibroblasts were treated with Boronophenylalanine and irradiated with thermal neutron flux. The electric potential of mitochondrial membrane, cyclin D1 and caspase-3 markers were analyzed.BNCT induced a cell death increase and cyclin D1 amount decreased only in B16F10 melanoma. Besides, there was not caspase-3 phosphorylation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 69, Issue 12, December 2011, Pages 1741–1744
نویسندگان
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