کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1880850 | 1399972 | 2016 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dosimetric and radiobiological comparison of volumetric modulated arc therapy, high-dose rate brachytherapy, and low-dose rate permanent seeds implant for localized prostate cancer
ترجمه فارسی عنوان
مقایسه دوزیمتریک و رادیو بیوژیک از روش قوس مدول اندازه گیری حجمی، براکیتریپیک با دوز بالا و میزان دائمی بذر دائمی برای ایمپلنت برای سرطان پروستات موضعی
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کلمات کلیدی
سرطان پروستات، تابش مدولاسیون حرارتی، ترشح تراپی با دوزاژ بالا، ایمپلنت بذر دائمی، دوز موثر زیستی،
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
چکیده انگلیسی
To investigate the dosimetric and radiobiological differences among volumetric modulated arc therapy (VMAT), high-dose rate (HDR) brachytherapy, and low-dose rate (LDR) permanent seeds implant for localized prostate cancer. A total of 10 patients with localized prostate cancer were selected for this study. VMAT, HDR brachytherapy, and LDR permanent seeds implant plans were created for each patient. For VMAT, planning target volume (PTV) was defined as the clinical target volume plus a margin of 5Â mm. Rectum, bladder, urethra, and femoral heads were considered as organs at risk. A 78Â Gy in 39 fractions were prescribed for PTV. For HDR and LDR plans, the dose prescription was D90 of 34Â Gy in 8.5Â Gy per fraction, and 145Â Gy to clinical target volume, respectively. The dose and dose volume parameters were evaluated for target, organs at risk, and normal tissue. Physical dose was converted to dose based on 2-Gy fractions (equivalent dose in 2Â Gy per fraction, EQD2) for comparison of 3 techniques. HDR and LDR significantly reduced the dose to rectum and bladder compared with VMAT. The Dmean (EQD2) of rectum decreased 22.36Â Gy in HDR and 17.01Â Gy in LDR from 30.24Â Gy in VMAT, respectively. The Dmean (EQD2) of bladder decreased 6.91Â Gy in HDR and 2.53Â Gy in LDR from 13.46Â Gy in VMAT. For the femoral heads and normal tissue, the mean doses were also significantly reduced in both HDR and LDR compared with VMAT. For the urethra, the mean dose (EQD2) was 80.26, 70.23, and 104.91Â Gy in VMAT, HDR, and LDR brachytherapy, respectively. For localized prostate cancer, both HDR and LDR brachytherapy were clearly superior in the sparing of rectum, bladder, femoral heads, and normal tissue compared with VMAT. HDR provided the advantage in sparing of urethra compared with VMAT and LDR.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Dosimetry - Volume 41, Issue 3, Autumn 2016, Pages 236-241
Journal: Medical Dosimetry - Volume 41, Issue 3, Autumn 2016, Pages 236-241
نویسندگان
Ruijie PhD, Nan MS, Anyan MD, Hao MD, Ang MD,