Phase correlation applied to the 3D registration of CT and CBCT image volumes

• Demonstration of 3D phase correlation registration algorithm use in radiotherapy.
• Evaluated using known transformations, added noise, and clinical CT and CBCT images.
• Successfully registers clinical images for use in adaptive radiotherapy.
• Potential advantages in efficiency by analysing in Fourier domain.

PurposeIn this study, a 3D phase correlation algorithm was investigated to test feasibility for use in determining the anatomical changes that occur throughout a patient's radiotherapy treatment. The algorithm determines the transformations between two image volumes through analysis in the Fourier domain and has not previously been used in radiotherapy for 3D registration of CT and CBCT volumes.MethodsVarious known transformations were applied to a patient's prostate CT image volume to create 12 different test cases. The mean absolute error and standard deviation were determined by evaluating the difference between the known contours and those calculated from the registration process on a point-by-point basis. Similar evaluations were performed on images with increasing levels of noise added. The improvement in structure overlap offered by the algorithm in registering clinical CBCT to CT images was evaluated using the Dice Similarity Coefficient (DSC).ResultsA mean error of 2.35 (σ = 1.54) mm was calculated for the 12 deformations applied. When increasing levels of noise were introduced to the images, the mean errors were observed to rise up to a maximum increase of 1.77 mm. For CBCT to CT registration, maximum improvements in the DSC of 0.09 and 0.46 were observed for the bladder and rectum, respectively.ConclusionsThe Fourier-based 3D phase correlation registration algorithm investigated displayed promising results in CT to CT and CT to CBCT registration, offers potential in terms of efficiency and robustness to noise, and is suitable for use in radiotherapy for monitoring patient anatomy throughout treatment.