کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1884873 | 1533330 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dosimetric benefit of adaptive re-planning in pancreatic cancer stereotactic body radiotherapy
ترجمه فارسی عنوان
مزایای دزیمتری از برنامه ریزی تطبیقی در پرتودرمانی بدن سترونوتاکتیک سرطان پانکراس
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
چکیده انگلیسی
Stereotactic body radiotherapy (SBRT) shows promise in unresectable pancreatic cancer, though this treatment modality has high rates of normal tissue toxicity. This study explores the dosimetric utility of daily adaptive re-planning with pancreas SBRT. We used a previously developed supercomputing online re-planning environment (SCORE) to re-plan 10 patients with pancreas SBRT. Tumor and normal tissue contours were deformed from treatment planning computed tomographies (CTs) and transferred to daily cone-beam CT (CBCT) scans before re-optimizing each daily treatment plan. We compared the intended radiation dose, the actual radiation dose, and the optimized radiation dose for the pancreas tumor planning target volume (PTV) and the duodenum. Treatment re-optimization improved coverage of the PTV and reduced dose to the duodenum. Within the PTV, the actual hot spot (volume receiving 110% of the prescription dose) decreased from 4.5% to 0.5% after daily adaptive re-planning. Within the duodenum, the volume receiving the prescription dose decreased from 0.9% to 0.3% after re-planning. It is noteworthy that variation in the amount of air within a patient׳s stomach substantially changed dose to the PTV. Adaptive re-planning with pancreas SBRT has the ability to improve dose to the tumor and decrease dose to the nearby duodenum, thereby reducing the risk of toxicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Dosimetry - Volume 40, Issue 4, Winter 2015, Pages 318-324
Journal: Medical Dosimetry - Volume 40, Issue 4, Winter 2015, Pages 318-324
نویسندگان
Yongbao B.S., Jeremy D.P. Ph.D., Nan B.S., Carrie Ph.D., Zhen Ph.D., Quentin M.S., Masoud Ph.D., Zhaoxia Ph.D., Yaqiang Ph.D., Xun Ph.D., Jona M.D., Loren K. M.D., Steve Ph.D., James D. M.D. M.S.,