کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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190572 | 459701 | 2010 | 6 صفحه PDF | دانلود رایگان |

A bismuth-film electrode for use in cathodic electrochemical detection was employed in order to quantify sulfadiazine in pharmaceutical formulations. The bismuth film was deposited ex situ onto a glassy carbon substrate. Analysis of two sulfa drugs was carried out by differential-pulse voltammetry in 0.05 mol L−1 Britton–Robinson pH 4.5 solution. Sulfadiazine reduction was observed at −0.74 V vs. Ag/AgCl in one well-resolved irreversible reduction peak. The analytical curve with two slopes was obtained in the concentration range of 3.2–97.0 μmol L−1. The detection limit was 2.1 μmol L−1 for concentrations of 3.2–20.0 μmol L−1 (r = 0.9949) and 12.2 μmol L−1 for concentrations between 20.0 and 97.0 μmol L−1 (r = 0.9951). Recovery studies carried out with both sulfadiazine samples gave values from 93.6 to 109.3%. The accuracy of the results supplied by the bismuth-film electrode was compared to those obtained by the standard amperometric titration method. The relative error between them was lower than 2.0%.
Journal: Electrochimica Acta - Volume 55, Issue 17, 1 July 2010, Pages 4970–4975