کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1906483 1046292 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of long-term fish oil-enriched diet on the sphingolipid metabolism in brain of old rats
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Effects of long-term fish oil-enriched diet on the sphingolipid metabolism in brain of old rats
چکیده انگلیسی

An increase of the neutral sphingomyelinase (SMase) activity in the animal brain at old age is associated with a higher expression of the inflammatory marker, interleukin-1β and a cognitive decline. Dietary n − 3 polyunsaturated fatty acids (n − 3 PUFA) are found to exhibit anti-inflammatory effects and normalize the age- or dementia-related cognitive function decline. In the paper we investigate the ceramide, sphingomyelin (SM) and phosphatidylserine (PS) levels in the hippocampus of 3-month-old-32-month-old rats as well as the correction of sphingolipid turnover in the brain of old rats by means of the dietetic fish oil and PS. To study the lipid turnover, the [14C]-labeled SM and palmitic acid were used. The [14C]ceramide level significantly increased while those of the [14C]SM, SM and PS levels decreased in the hippocampus of aged rats as compared with 3-month-old animals. Treatment of the rats with the fish oil or PS reduced the [14C]ceramide content and neutral SMase activity in the hippocampus of the 24-month-old animals with respect to control rats of the same age. These results suggest that dietary n − 3 PUFA can prevent the age-dependent abnormalities of sphingolipid turnover via increased PS content in the hippocampus of old rats.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 45, Issue 5, May 2010, Pages 375–380
نویسندگان
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