کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1909800 | 1046740 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Insulin action mechanism for redox signaling in the cell cycle: Its alterations in diabetes
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Insulin action mechanism for redox signaling in the cell cycle: Its alterations in diabetes Insulin action mechanism for redox signaling in the cell cycle: Its alterations in diabetes](/preview/png/1909800.png)
چکیده انگلیسی
Several reports describe the existence of a redox cycle within the normal cell cycle that helps control the process of cell proliferation. According to some of these reports, this redox cycle comprises an intracellular redox potential E that oscillates above and below θ during the cell cycle process. θ is the threshold for dephosphorylation of protein regulators associated with serine residues such as the retinoblastoma protein. This article describes how insulin action may be the source of the redox cycle within the cell cycle. The relative lack of insulin action as a consequence of oxidative stress results in the hallmarks of type 2 diabetes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 47, Issue 7, 1 October 2009, Pages 1093–1097
Journal: Free Radical Biology and Medicine - Volume 47, Issue 7, 1 October 2009, Pages 1093–1097
نویسندگان
Arnold Hoffman,