کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1910889 | 1046792 | 2008 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Protein tyrosine nitration—Functional alteration or just a biomarker? Protein tyrosine nitration—Functional alteration or just a biomarker?](/preview/png/1910889.png)
Protein 3-nitrotyrosine is a posttranslational modification found in many pathological conditions from acute to chronic diseases. Could 3-nitrotyrosine formation participate on the basis of these diseases or is it just a marker connected with the associated nitroxidative stress? In vitro and in vivo data, including proteomic research, show that protein tyrosine nitration is a selective process where only a small amount of proteins is found nitrated and one or a few tyrosine residues are modified in each. Accumulating data suggest a strong link between protein 3-nitrotyrosine and the mechanism involved in disease development. In this review, we analyze the factors determining protein 3-nitrotyrosine formation, the functional and biological outcome associated with protein tyrosine nitration, and the fate of the nitrated proteins.
Journal: Free Radical Biology and Medicine - Volume 45, Issue 4, 15 August 2008, Pages 357–366