کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1911096 1046801 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comparisons between the beneficial effects of different sulphonylurea treatments on ischemia-induced retinal neovascularization
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Comparisons between the beneficial effects of different sulphonylurea treatments on ischemia-induced retinal neovascularization
چکیده انگلیسی

The aim of this study was to assess the potential beneficial effects of gliclazide and other sulphonylureas on ischemia-induced retinal neovascularization. To produce an animal model of oxygen-induced ischemic retinopathy, 7-day-old (P7) mice were exposed to a 75% oxygen environment for 5 days. On their return to ambient air at P12, these mice were then treated with gliclazide, glibenclamide, glimepiride, or N-acetylcysteine. Gliclazide, but not glibenclamide or glimepiride, markedly suppresses retinal neovascularization. N-Acetylcysteine, however, only moderately suppresses retinal neovascularization. The number of neovascular nuclei in the retinal cross sections decreased by 29% in the gliclazide-treated mice (P < 0.05 vs control). The induction of VEGF mRNA expression at P13 is significantly suppressed in the gliclazide group, relative to the control group (− 44%, P < 0.05). The VEGF protein expression levels at P15 were also suppressed in the gliclazide group (− 43%, P < 0.01). The 8-isoprostane production levels at P15 were suppressed in both the gliclazide group (− 20%, P < 0.05) and the N-acetylcysteine-treated group (− 31%, P < 0.01). Gliclazide inhibits ischemia-induced retinal neovascularization, and this is likely to be mediated in part through the downregulation of VEGF and the suppression of oxidative stress.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 43, Issue 3, 1 August 2007, Pages 454–461
نویسندگان
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