کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1919175 1535605 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Elevated galanin may predict the risk of type 2 diabetes mellitus for development of Alzheimer’s disease
ترجمه فارسی عنوان
افزایش گالانین ممکن است خطر ابتلا به دیابت نوع 2 را برای بیماری آلزایمر پیش بینی کند
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی


• Galanin increases insulin sensitivity in human and rodent models.
• Upregulation of galanin in Alzheimer’s disease is a protective factor to the disease.
• Galanin are implicated in the cross-talk between both disease.

Alzheimer’s disease is the most common form of dementia among the elderly and is characterized by progressive loss of memory and cognition. Epidemiological and clinical studies demonstrated that type 2 diabetes mellitus is an important risk factor for the development of Alzheimer’s disease, i.e., the patients with type 2 diabetes mellitus are frequently companied with Alzheimer’s disease symptoms. Despite many studies recently probed into the comorbid state of both diseases, so far the precise mechanism for this association is poorly understood. Emerging evidences suggest that defects in galanin play a central role on type 2 diabetes mellitus and is considered to be a risk factor for Alzheimer’s disease development. This review provides a new insight into the multivariate relationship among galanin, type 2 diabetes mellitus and Alzheimer’s disease, highlighting the effect of galanin system on the cross-talk between both diseases in human and rodent models. The current data support that activating central GalR2 attenuates insulin resistance and Alzheimer’s disease feature in animal models. These may help us better understanding the pathogenesis of both diseases and provide useful hints for the development of novel therapeutic approaches to treat type 2 diabetes mellitus and Alzheimer’s disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mechanisms of Ageing and Development - Volume 150, September 2015, Pages 20–26
نویسندگان
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