کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1919222 1535620 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structure, function and regulation of CSB: A multi-talented gymnast
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Structure, function and regulation of CSB: A multi-talented gymnast
چکیده انگلیسی

The Cockayne syndrome complementation group B protein, CSB, plays pivotal roles in transcription regulation and DNA repair. CSB belongs to the SNF2/SWI2 ATP-dependent chromatin remodeling protein family, and studies from many laboratories have revealed that CSB has multiple activities and modes of regulation. To understand the underlying mechanisms of Cockayne syndrome, it is necessary to understand how the biochemical activities of CSB are used to carry out its biological functions. In this review, we summarize our current knowledge of the structure, function and regulation of CSB, and discuss how these properties can impact the biological functions of this chromatin remodeler.


► Mechanisms of CSB–chromatin interaction.
► ATP-dependent CSB activities.
► ATP-independent CSB activities.
► CSB modification and oligomerization.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mechanisms of Ageing and Development - Volume 134, Issues 5–6, May–June 2013, Pages 202–211
نویسندگان
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