Overexpression of PaParp encoding the poly(ADP-ribose) polymerase of Podospora anserina affects organismal aging

▶ Podospora anserina genome encodes for a bona fide PARP. ▶ Overexpression of PARP in P. anserina leads to phenotypical deficiencies. ▶ PaParp overexpression leads to mitochondrial impairments. ▶ PaParp overexpressors display increased sensitivity to stressors. ▶ PaParp overexpressors are characterized by an increased sensitivity towards apoptosis.